Synthesis of Cis-Diammine (1,1-cyclobutane dicarboxylate) Platinum(II)

Platinum-based anticancer drugs are chemotherapeutic agents to treat cancer. Carboplatin (cis diammine cyclobutane dicarboxylate platinum (II)) is a second generation drug that has less toxic than cisplatin, allowing for high dosages. In the first stage, 1,3-Cyclobutane dicarboxylic acid, a key intermediate for the preparation of carboplatin, have been synthesized in good yields using different methodology to achieve high purity then carboplatin was synthesized from the reaction of the prepared ligand with cisplatin. Purity of prepared carboplatin was confirmed by High-Performance Liquid Chro­matography (HPLC). Platinum(II) complex carboplatin,have been characterized with  1H and 13C nuclear magnetic resonance spectra and infrared spectroscopy.